Service · Specialised

Selective plasma exchange, done right.

Plasmapheresis for immune-mediated kidney and systemic disease — vasculitis, lupus, antibody-mediated transplant rejection, neurological autoimmune emergencies.

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What it is

How plasmapheresis differs from regular dialysis.

Plasmapheresis is the broader family of treatments that separate your blood into cells and plasma, then put one or both back. The plasma carries antibodies and inflammation drivers — in autoimmune disease, the plasma is the problem.

By selectively removing plasma and replacing it with albumin or donor plasma (FFP), we strip out the antibodies that are attacking the kidneys, nerves, or lungs. It is rescue therapy for the antibody-mediated end of medicine.

At Renacare, plasmapheresis is nephrologist-supervised, protocol-driven, and run on dedicated apheresis machines. We use it for kidney indications (vasculitis, lupus nephritis flare, transplant rejection) and partner with neurology and haematology for theirs (Guillain-Barré, myasthenia, TTP).

"Apheresis works when the team running it understands the disease, not just the machine."

How we do it differently

Specialised therapy. Specialist team.

Plasmapheresis machines are everywhere. The discipline behind them isn't.

Indication-led

Evidence over enthusiasm

We offer plasmapheresis only for conditions where international guidelines support benefit. Wishful thinking does not get a treatment course at Renacare.

Reliable access

Tunnelled or large-bore line

Most courses are 5–7 sessions on alternate days. A reliable line up front means no session is missed and no access trauma builds up.

Replacement strategy

Albumin, FFP, or hybrid

Replacement fluid choice is matched to your indication, bleeding risk, and immunoglobulin status. We do not default — we decide.

Joint care

Nephrology, haematology, neurology

Most plasmapheresis indications cross specialties. Our nephrologists run apheresis but co-manage with the relevant specialist. One patient, one plan.

What to expect

From referral to remission.

Most courses run 5–7 sessions over 10–14 days, sometimes longer.

Indication review

Nephrologist confirms diagnosis and indication. Baseline labs: antibodies, IgG, clotting, complement, kidney function. Consent.

Access placement

Tunnelled or large-bore temporary line placed under ultrasound. Same-day procedure, low complication rate.

Course of sessions

5–7 alternate-day sessions on apheresis machine. Replacement fluid prescribed per indication. Vitals, calcium, and clotting monitored throughout.

Response review

After course: antibody titers, clinical signs, end-organ markers reviewed. Maintenance plan or completion. Follow-up with primary specialist coordinated.

Frequently asked

Questions worth asking.

Before you start a treatment anywhere — these are the questions to ask. We've answered ours.

How is plasmapheresis different from TPE?

Therapeutic Plasma Exchange (TPE) is a type of plasmapheresis. "Plasmapheresis" is the umbrella term that includes TPE and other selective techniques (immunoadsorption, double-filtration). At Renacare we offer TPE primarily; selective techniques case-by-case.

Will I feel different after sessions?

Most patients feel fatigued for a few hours and notice symptom improvement over the course. Side effects like tingling around the lips (citrate effect) and mild blood pressure changes are common but manageable.

Is plasmapheresis a cure?

It is rescue and bridge therapy. It removes the antibodies driving the disease right now, but it does not stop your body making new ones — that's why immunosuppression usually runs alongside. Together they can achieve remission.

What conditions do you offer it for?

Kidney indications: ANCA vasculitis with pulmonary haemorrhage, antibody-mediated transplant rejection, anti-GBM disease (Goodpasture), severe lupus nephritis. Plus partnerships with neurology and haematology for TTP, GBS, myasthenia, and other antibody-mediated conditions.

Talk to a nephrologist.

Whether you're starting dialysis, switching centres, or just want a second opinion — one conversation tells you everything you need.

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